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3
Current numerical and waveform displays do not
support anaesthesiologists optimally
Drews et.al. The right picture is worth a thousand numbers: data display in anesthesia. HUMAN
FACTORS 2006, Vol 48
Mechanical Ventilation
GraphicsGraphicsSCALARS LOOPS
Essentials of Ventilator Graphics ©2000 RespiMedu
5
Flow PatternsFlow Patterns
ACCELERATINGACCELERATING
DECELERATINGDECELERATING
SINESINE
SQUARESQUARE
Essentials of Ventilator Graphics ©2000 RespiMedu
Expiratory Flow PatternExpiratory Flow Pattern
Inspiration
Expiration
Time (sec)
Flo
w (
L/m
in)
Beginning of expirationexhalation valve opens
Peak Expiratory Flow RatePEFR
Duration of expiratory flow
Expiratory timeTE
6
Air Leak (Flow Trigger)Air Leak (Flow Trigger)
InspirationInspiration
ExpirationExpiration
Time (sec)Time (sec)
Flo
w (
L/m
in)
Flo
w (
L/m
in)
Leak in LPMLeak in LPM
Air TrappingAir Trapping
Inspiration
Expiration
NormalNormal
PatientPatient
Time (sec)
Flo
w (
L/m
in)
Air TrappingAuto-PEEP
}
7
Inadequate Inspiratory FlowInadequate Inspiratory Flow
Flow Flow
(L/min)(L/min)
Time (sec)Time (sec)
NormalNormal
AbnormalAbnormal
Active Inspiration or AsynchronyActive Inspiration or Asynchrony
Patient’s effort
Obstruction vs Active ExpirationObstruction vs Active Expiration
Obstruction Active Expiration
Time
(sec)
NormalAbnormal
Flow
(L/min)
8
Response to BronchodilatorResponse to Bronchodilator
Before
Time (sec)
Flo
w (
L/m
in)
PEFR
After
Long TE
Higher PEFR
Shorter TE
Spontaneous BreathSpontaneous Breath
PPaw
aw
(cm
H(c
m H
220
)0
)
Time (sec)Time (sec)
InspirationInspiration
ExpirationExpiration
9
Mechanical BreathMechanical Breath
InspirationExpiration
Paw
(cm
H2O
)
Time (sec)
}}TI
Peak Inspiratory PressurePIP
PEEPPEEP
TE
Spontaneous vs. Mechanical
MechanicalMechanical
Time (sec)
SpontaneousSpontaneousPaw
(cm H2O)
Inspiration
ExpirationExpiration
Inspiration
11
Components of Inflation Pressure
Components of Inflation Pressure
Begin Expiration
Paw
(cm
H2O
)
Time (sec)
Begin Inspiration
PIPPIP
Pplateau(Palveolar)
Transairway Pressure (PTA)}}Exhalation Valve Opens
ExpirationExpiration
Inspiratory Pause
12
Begin InspirationBegin Expiration
Pa
w(c
m H
2O
)
Time (sec)
Airway Resistance
Distending (Alveolar) Pressure Expiration
Inflation Hold(seconds)
Begin Expiration
Pa
w(c
m H
2O
))
Time (sec)Begin Inspiration
PIPPIP
Pplateau(Palveolar
TransairwayTransairway Pressure (PPressure (PTATA))}}Exhalation Valve Opens
Expiration
PIP
13
DECREASED COMPLIANCEDECREASED COMPLIANCE
Time (sec)
Paw
(c
m H
2O
)
Low CompliancePIP
PPlat
NormalNormal
PIP
PPlat
Normal PPlat(Normal Compliance)
Increased PPlat(Decreased Compliance))
Normal
PIP
Paw
(c
m H
Paw
(c
m H
22O
)O
)
Normal
Normal PPlat(Normal Compliance)
Increased PIP
} Increased PTA(increased Airway Resistance))
NormalNormalPIPPIP
PPPlatPlat
High RHigh RawawPIPPIP
PPPlatPlat
Increased Airway Resistance
14
Effect of increased FlowEffect of increased Flow
Time (sec)
Paw
(c
m H
2O
)
NormalNormalPIPPIP
High FlowHigh Flow
PPlat
PIPPIP
Dynamic Inspiratory TimeDecreased Inspiratory TimeInspiratory Time(Due to High Inspiratory Flow)
Normal
PPlat
PIP vs PplatPIP vs Pplat
Normal High Raw
High Flow Low Compliance
Time (sec)
Paw
(c
m H
2O
)
PIPPIP
PPPlatPlat
PIPPIP
PIPPIP PIPPIP
PPPlatPlatPPPlatPlat
PPlat
15
Volume vs. TimeVolume vs. Time
InspirationInspiration
Expiration
Time (sec)Time (sec)
Vo
lum
e (
ml)
Vo
lum
e (
ml)
Inspiratory Tidal VolumeInspiratory Tidal Volume
TTII
Essentials of Ventilator Graphics ©2000 RespiMedu
Air LeakAir Leak
Vo
lum
e (
ml)
Vo
lum
e (
ml)
Time (sec)Time (sec)
Air LeakAir Leak
Essentials of Ventilator Graphics ©2000 RespiMedu
17
Modes of Ventilation on Scalar Graphics
Modes of Ventilation on Scalar Graphics
FLOW
PRESSURE
VOLUME
Volume VentilationVolume Ventilation
PressurePressure
Volume Volume Volume
FlowFlowPreset Peak FlowPreset Peak Flow
Preset Preset VVtt
Dependent onDependent on
CCll & R& Rawaw
Time (sec)Time (sec)
(L/min)(L/min)
(cm H(cm H22O)O)
(ml)(ml)
18
Pressure Control Ventilation
Pressure Control Ventilation
FlowFlow
PressurePressure
VolumeVolumeCCll
CCll
Set PC levelSet PC level
Time (sec)Time (sec)
(L/min)(L/min)
(cm H(cm H22O)O)
(ml)(ml)
Controlled Mode (Volume-Targeted Ventilation)
Controlled Mode (Volume-Targeted Ventilation)
Preset VT
Volume Cycling
Dependent on
CL & Raw
Time (sec)Time (sec)
Flow
(L/m)
Pressure
(cm H2O)
Volume
(mL)
Preset Peak Flow
Time triggered, Flow limited, Volume cycled Ventilation
19
Controlled Mode (Pressure-
Targeted Ventilation)
Controlled Mode (Pressure-
Targeted Ventilation)
Pressure
Flow
Volume
(L/min)
(cm H2O)
(ml)
Time (sec)Time (sec)
TimeTime--Cycled
Set PC level
Time Triggered, Pressure Limited, Time Cycled Ventilation
PSVPSV
Time (sec)
Flow(L/m)
Pressure(cm H2O)
Volume(mL)
Flow CyclingFlow Cycling
Set PS level
Set PS level
Patient Triggered, Flow Cycled, Pressure limited Mode
20
SIMV(Volume-Targeted Ventilation)
SIMV(Volume-Targeted Ventilation)
Spontaneous Breaths
Flow(L/m)
Pressure(cm H2O)
Volume(mL)
Pressure
Flow
Volume
(L/min)
(cm H2O)
(ml)
Set PC levelSet PC level
Time (sec)Time (sec)
SIMV Mode (Pressure-Targeted Ventilation)
SIMV Mode (Pressure-Targeted Ventilation)
Spontaneous Breath
21
Pressure
Flow
Volume
(L/min)
(cm H2O)
(ml)
SIMV + PS (Pressure-Targeted Ventilation)
SIMV + PS (Pressure-Targeted Ventilation)
PS Breath
Set PS levelSet PC levelSet PC level
Time (sec)
Time-Cycled Flow-Cycled
Spontaneous Breath
Time (sec)
Flow(L/m)
Pressure(cm H2O)
Volume(mL)
22
CPAPCPAP
Time (sec)Time (sec)
CPAP level
Flow
(L/m)
Pressure
(cm H2O)
Volume
(mL)
CPAP + PSVCPAP + PSV
Set PS level
CPAP level
Time (sec)Time (sec)
Flow(L/m)
Pressure(cm H2O)
Volume(mL)
Flow Cycling
26
Components of breath delivery
Triggering Inspiration Cycling Expiration
Flow
Time
吸氣啟動吸氣啟動吸氣啟動吸氣啟動 (Trigger)
• 壓力啟動壓力啟動壓力啟動壓力啟動 (Pressure trigger)
• 氣流啟動氣流啟動氣流啟動氣流啟動 (Flow trigger)
27
Start of inhalation: Patient
trigger
Paw
Time
Pressure trigger
Flow
Time
Flow trigger
吸氣氣流的調整
• 吸氣早期
-Rise time percent
• 氣流自動調整
-Autoflow, Evita 4
29
吸氣結束(Expiratory sensitivity)
• 壓力支持型呼吸的吸氣停止多為吸
氣氣流降於起始氣流的25%
• 吐氣靈敏度即為氣流降至起始氣流
的百分比,是可以調整的
Cycling with ETS
Flow
Time
30
Effects of flow triggering on breathing effort during partial ventilatory support.
Aslanian P, El Atrous S, Isabey D, Valente E, Corsi D, Harf A, Lemaire F, Brochard L.
Am J Respir Crit Care Med. 1998 Jan;157(1):135-43.
31
-0,6
-0,4
-0,2
0
0,2
0,4
0,6
0
4
8
12
16
20
0 2 4 6 8
Ineffective Triggering
Flow (L/s)
Airway Pressure (cmH20)
Time (s)
Increase of flow
Decrease of pressure
Wasted effort
34
自發性呼氣末端正壓自發性呼氣末端正壓自發性呼氣末端正壓自發性呼氣末端正壓(Auto-PEEP,or Intrinsic-PEEP)
• 病患用力吐氣,氣道外壓力高於氣道內壓力
引起氣道狹窄,甚至塌陷
• 在吐完氣後,氣道仍可測得殘餘正壓
• 在吸氣時,更要費力產生負壓,以擴張塌陷的氣道
• 呼氣呼不完全,肺泡撐得較大
• 吸氣時,必須面對更大的彈性阻抗
• 吸氣作功會增加
36
V= 30 l/min (0,5 l/s)
V= 90 l/min (1,5 l/s)
Kondili et coll, BJA 2003
Effect of different inspiratory rise time and cycling off criteria during pressure support ventilation in
patients recovering from acute lung injury
Davide Chiumello; Paolo Pelosi; Paolo Taccone; Arthur Slutsky; Luciano Gattinoni
Crit Care Med 2003; 31:2604 –2610
37
-1,5
-1
-0,5
0
0,5
1
1,5
0
10
20
30
40
50
0 2 4 6 8
Double Triggering
Double
Triggering
Flow (L/s)
Airway Pressure (cmH20)
Time (s)
38
Flow-Volume LoopFlow-Volume Loop
Volume (ml)Volume (ml)
PEFR
FRC
Inspiration
Expiration
Flow (L/min)
Flow (L/min)
PIFR
VT
Components of Pressure-Volume Loop
Components of Pressure-Volume Loop
Volume Volume
((mLmL))
Inspiration
Expiration
PIP
VT
PPawaw (cm H(cm H22O)O)
39
HysteresisHysteresis
Volume (ml)
Pressure (cm HPressure (cm H22O)O)
Abnormal Hysteresis
Normal Hysteresis
Type of BreathType of Breath
ControlledControlled AssistedAssisted Spontaneous
PPawaw
(cm H(cm H22O)O)
I: Inspiration
E: Expiration
I E
E
I
E
I
40
Decreased ComplianceDecreased Compliance
Volu
me(m
l)
Pressure (cm HPressure (cm H22O)O)
NormalNormal
PatientPatient
Increased RawIncreased Raw
Pressure (cm HPressure (cm H22O)O)
Higher PTA
Normal Slope
Normal Slope
VolVol ((mLmL))
Lower
Slop
e
Lower
Slop
e
41
Inadequate Inspiratory FlowInadequate Inspiratory Flow
PPaw aw (cm H(cm H22O)O)
Volume Volume
(ml)(ml)
NormalNormal
AbnormalAbnormal
Active InspirationActive Inspiration
Inappropriate FlowInappropriate Flow
Inadequate SensitivityInadequate Sensitivity
Volume Volume
((mLmL))
PPawaw (cm H(cm H22O)O)Increased WOB
42
Air LeakAir Leak
Volume (ml)
Pressure (cm HPressure (cm H22O)O)
Air Leak
Inflection PointsInflection Points
Pressure (cm H2O)
Volume (mL)
Upper Inflection Point
Lower Inflection Point
43
OverdistensionOverdistension
Volu
me (m
l)
Pressure (cm HPressure (cm H22O)O)
With little or no change in VTWith little or no change in VT
Paw risesPaw rises
NormalAbnormal
44
Work of BreathingWork of Breathing
A: Resistive WorkB: Elastic Work
Pressure (cm H2O)
Volume (ml)
BBB
AAA
PEEP and P-V LoopPEEP and P-V Loop
Volume
(mL)
VT
PIPPIPPaw (cm H2O)
PEEP PEEP
45
Inflated 0
Alveolar Collapse(Reabsorption) 40-60 cmH2O
SuperimposedPressure
OpeningPressure
Consolidation ∞∞∞∞
(modified from Gattinoni))
Small AirwayCollapse
10-20 cmH2O
ARDS lung is multicompartimentalRegional Spectrum of Opening
Pressures
Vo
lum
e
Hysteresis of the P/V curve
Airway Pressure
47
Hysteresis as an index of collapse re-expansion
6 798 cmH2O.ml 25 115 cmH2O.ml
� Pressure (cmH2O)
� 0 � 10 � 20 � 30 � 40 � 50
�V
olu
me
(ml) � 0
� 500
� 1000
� 1500
� 2000
� 2500
� 3000
� Pressure (cmH2O)
� 0 � 10 � 20 � 30 � 40 � 50
�V
olu
me
(ml)
� 0
� 500
� 1000
� 1500
� 2000
� 2500
� 3000
Volume recruited by a recruitment maneuver
48
Alveolar volume change during tidal breathing
Di Rocco. Intensive Care Med 2007
Setting PEEP according to deflation PV curve
49
Hickling.
AJRCCM 2001
Alveoli with
highest closing pressure start to
collapse
Most of alveoli
collapse with indicates the
open-lung PEEP
Setting PEEP according to deflation PV curve
ASV Target Graphics Window
50
WOB as function of rate
0
0.02
0.04
0.06
0.08
0.1
0.12
0.14
0.16
0 10 20 30 40 50
Respiratory Rate in bpm
WO
B in
Jo
ule
/se
c
elastic
resist.
total
0
500
1000
1500
2000
0 20 40 60
RR (b/min)
TV
(m
L)
COPD, asthma,
emphysema
ARDS, fibrosis,
pneumonia
Adapted Support
ventilation
51
����Pinsp
����RRIMV
����Pinsp
����RRIMV
����Pinsp
����RRIMV
���� Pinsp
����RRIMV
Adaptive Support Ventilation
(Pmax-PEEP)*Cdyn
5 b/min 20/RCexp
2*Vd
NAVA Preview
53
ARDS – After Recruitment
See all important information at a glance
resistance compliancetidal
volume
inspiratory
time
54
PEEP
See all important information at a glance
FiO2
FiO2 RSB%fSpontExp
MinVolPinsp
Improve SA: Inform on present status
� symmetric lung, nicely
moving
� no airway obstruction
� patient activity
� oxygenation OK
� CO2 elimination OK
� sponaneous activiy OK
55
Example ARDS� asymmetric stiff lung
� slight airway
obstruction
� no patient activity
� oxygenation not OK
� CO2 elimination not OK
� sponaneous activiy not OK
=> No alarm – patient and ventilator states are consistent
Performance of the Ventilation Cockpit
Traditional – Flow Volume Spirometry Graphic Display – Dynamic Lung
Performance with & without the Dynamic Lung from the Hamilton G5 Ventilator
Robert Albert; Noah Syroid; James Agutter; Dwayne Westenskow - Society for Technology in Anesthesia; Jan 2008